How a Japanese herbal remedy Prevents Inflammatory Bowel Disease in the Gut



Colitis is one of two disorders that make up inflammatory bowel disease.

The inner colonic lining becomes inflamed in colitis, a persistent digestive condition. An inflammatory colon may be brought on by an infection, a lack of blood flow to the colon, IBD, collagen or lymphocytic white blood cell invasion, or any of several other conditions. The inner colonic lining becomes inflamed in the colon, a persistent digestive condition. 

Different Kinds of Colon Diseases

types of colitis

Colitis comes in a wide variety of forms, including:

  • inflammatory colitis 
  • ulcerative colitis
  • Crohn’s disease
  • Dialectical colitis
  • Hemorrhagic colitis
  • Chronic colon inflamation
  • Collagen related colitis
  • Colitis caused by chemicals
  • Microscopic colitis
  • Lymphocytic colitis
  • Atypical colitis

Symptoms of colon inflammation

Warning signals colon inflammation are:

  • a severe pain
  • abdomen sensitivity
  • Depression
  • rapid loss of weight
  • joint pain and stiffness
  • reduced appetite
  • Fatigue
  • alterations to bowel habits (increased frequency)
  • Fever
  • tissue in the colon swells
  • erythema (redness) on the colon’s surface
  • colonic ulcers that may bleed (in ulcerative colitis)
  • feces containing blood or mucus and/or rectal hemorrhage


Although some types of colitis cause constipation, which can cause diarrhea, the stool and bowel movements may still seem normal.

Other signs and symptoms may include gastrointestinal discomforts such as gas, bloating, indigestion, heartburn, gastroesophageal reflux disease, cramps, and bowel urgency.

Treatment for colitis is based on traditional Japanese herbal medicine.

Zhengzheng Shi and associates at the RIKEN Center for Integrative Medical Sciences (IMS) in Japan report on the effects of a typical herbal cure on IBD.

The study, which was published in Frontiers in Immunology, demonstrates that DKT, a common supplement made up of ginger, pepper, ginseng, and maltose, lessened the severity of colitis in lab mice by preventing the typical imbalance in gut microbes and by raising the number of immune cells that fight inflammation in the colon.

A persistent inflammation of the colon known as colitis is characterized by a bacterial imbalance in the gut and an inappropriate immunological response. Currently a global health concern, it has doubled in prevalence over the past 20 years and is most prevalent in Europe and North America. Although there are many different treatments, many are only partially successful.

This has prompted some academics to examine traditional herbal remedies more closely, which were first used in China and are now widely utilized in Japan and other Asian nations.

One of the 148 herbal remedies known as Kampo that have been produced in Japan and are frequently given by doctors to treat a range of illnesses is 犀利士
” rel=”noopener”>Daikenchuto (DKT), a formula comprising particular proportions of ginger, pepper, ginseng, and maltose.

DKT may be helpful in curing colon diseases, according to an earlier study, but there hasn’t been much proof of this, particularly at the molecular level. As a result, Shi and the RIKEN IMS research team, led by Naoko Satoh-Takayama, thoroughly investigated its results on a mouse model of colitis.

Dextran sodium sulfate, which is harmful to the cells that line the colon, was used to induce colitis in mice. These mice’s body weights remained normal after receiving DKT, and their clinical colitis scores decreased. The cells lining the colon had significantly less damage, according to an additional study.

After demonstrating that DKT does, in fact, aid in the prevention of colitis, the researchers examined the mice’s gut microbiomes and the levels of expression of immune cells that fight inflammation.

Crohns vs. Colitis

Numerous bacteria and fungi found in gut microbiomes support the immune system and aid digestion.

Analysis revealed that a family of lactic acid bacteria was decreased in the colitic mice in this study, which is consistent with colitis‘ association with an imbalance in these gut microbiotas. One of their metabolites, the short-chain fatty acid propionate, was also decreased.

When the model mice were given DKT, many of these missing bacteria, especially those belonging to the species Lactobacillus, were recovered, and propionate levels returned to normal.

Additionally, an aberrant immune response resulting from the typical intestinal inflammation is linked to colitis.

When the team examined innate intestinal immune cells, they discovered that ILC3 levels were lower in the untreated colitic mice than in the colonic mice that had received DKT treatment. They also discovered that mice created to lack ILC3 suffered more and were not as responsive to DKT treatment.

It follows that DKT functions by interacting with ILC3s, which are essential for preventing colon diseases. Last but not least, qPCR analysis revealed that these significant immune cells carried GPR43 propionate receptors on their surface.

According to Satoh-Takayama, “Daikenchuto is frequently prescribed to prevent and treat gastrointestinal illnesses as well as to lessen intestinal blockage following colon cancer surgery.”

Here, we have demonstrated that by rebalancing the amounts of lactobacillus in the gut microbiome, it can also treat intestinal illnesses like colitis. By encouraging the function of type 3 innate lymphoid cells, this probably reduces inflammatory immune responses.

Natural treatment for colitis in Philadelphia

If you suffer from any form of colon illnesses and prefer to treat it naturally, Philadelphia Homeopathic Clinic could be your best choice. At the clinic, Dr. Tsan leads a team of licensed medical professionals. We provide treatment using acupuncture, homeopathy, Chinese medicinal herbs, Ayurveda, and more. All services are performed under one roof in our central office located in the Northeast region of Philadelphia.

Contact the clinic to schedule an appointment with Dr. Tsan and to discuss which treatment options are best for you. You can also schedule your appointment for an initial evaluation using our secure online application by clicking on the bar below.

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